Kappa Opioids, Salvinorin A and Major Depressive Disorder
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چکیده
منابع مشابه
Kappa Opioids, Salvinorin A and Major Depressive Disorder
Opioids are traditionally associated with pain, analgesia and drug abuse. It is now clear, however, that the opioids are central players in mood. The implications for mood disorders, particularly clinical depression, suggest a paradigm shift from the monoamine neurotransmitters to the opioids either alone or in interaction with monoamine neurons. We have a special interest in dynorphin, the las...
متن کاملMajor Depressive Disorder and Kappa Opioid Receptor Antagonists
Major depressive disorder (MDD) is a common psychiatric disease worldwide. The clinical use of tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs) and selective serotonin reuptake inhibitors (SSRIs)/serotonin-norepinephrine reuptake inhibitor (SNRIs) for this condition have been widely accepted, but they were challenged by unacceptable side-effects, potential drug-drug intera...
متن کاملSheehan’s Syndrome Presenting as Major Depressive Disorder
Sheehan’s syndrome or Simmond’s disease is a rare endocrine disorder seen in clinical practice. The clinical spectrum is diverse and a high index of suspicion together with a good clinical acumen and proper diagnostic approach helps in early diagnosis and prompt treatment of this endocrinopathy. Sheehan’s syndrome presenting as a major depressive disorder finds less mention in the literature.Th...
متن کاملStandard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers.
Protection of salvinorin B as standard alkoxyalkyl ethers yielded highly potent kappa opioid receptor agonists. Ethoxymethyl ether 6 is among the most potent and selective kappa agonists reported to date. Fluoroethoxymethyl ether 11 is the first potent, selective fluorinated kappa ligand, with potential use in MRI and PET studies. Further enlargement of the alkoxy group, alkylation of the aceta...
متن کاملMajor depressive disorder.
Copyright © 2008 Massachusetts Medical Society. Depression is related to the normal emotions of sadness and bereavement, but it does not remit when the external cause of these emotions dissipates, and it is disproportionate to their cause. Classic severe states of depression often have no external precipitating cause. It is difficult, however, to draw clear distinctions between depressions with...
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ژورنال
عنوان ژورنال: Current Neuropharmacology
سال: 2016
ISSN: 1570-159X
DOI: 10.2174/1570159x13666150727220944